Joseph V. Bonventre, M.D., Ph.D.
Dr. Bonventre is Chief of the Division of Renal Medicine and Chief of the Division of Engineering in Medicine at Brigham and Women’s Hospital, and Samuel A. Levine Professor of Medicine at Harvard Medical School. He has had a long-standing interest in various aspects of cellular injury and repair mechanisms in the kidney. He established the origin of the epithelial cells that repair the kidney after injury as dedifferentiated surviving proximal tubule cells, and he was the first to describe the role of proximal tubule cell cycle arrest in the maladaptive fibrosis that can occur after severe injury leading to chronic kidney disease. He also discovered and characterized kidney injury molecule-1 (KIM-1) as the most highly upregulated protein in the proximal tubule after injury to the kidney of various types. He established a technique to differentiate human stem cells to kidney tissue and his protocol is being used throughout the world. The most highly cited person in the field of AKI, Dr. Bonventre is past-president of the American Society of Nephrology, past director of the Harvard MIT Division of Health Sciences and Technology, and founding director of the kidney group of the Harvard Stem Cell Institute.