Other Kidney Diseases

In addition to acute kidney injury and polycystic kidney disease, our MNP technology platform may be used for the development of targeted therapeutics to treat other renal tubular diseases, such as:

  • Cystinuria
  • Renal tubular acidosis
  • Lysinuric protein intolerance
  • Adenine-phosphoribosyl-transferase deficiency
  • Dent disease

Further, it is now well recognized that adverse cross talk between the tubules and the glomerulus plays an important role in the progression of chronic kidney disease in all settings, whether there is initial isolated tubulointerstitial injury or combined glomerular/tubular injury. Among these are rare disorders such as autosomal dominant tubulointerstitial kidney disease (ADTKD) as well as chronic kidney disease of different etiologies, including diabetic and hypertensive nephropathy.

Finally, Goldilocks is exploring approaches to target the glomerulus directly, which would open the possibility of treating a variety of primary glomerular diseases including IgA nephropathy, membranous nephropathy, minimal change disease and focal segmental glomerulosclerosis among others.